The Lady Patriots fell 55-38 in their first home game of the season.
West Limestone broke open a close game at the half, 20-18, by outscoring Brewer 35-20 in the second half.
Chloe Romine led Brewer (1-1) with 13 points and five steals. Jacey Atkinson and Lilly Yancey had six points each, while Bailey Hale added five points and ten rebounds.