2021-10-21 19:00:0010/21/2021 | Brooks | 0 - 47 | Wilson ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/wilson.png?fit=32%2C32) | Ralph Thompson Stadium |
2021-10-21 19:00:0010/21/2021 | West Limestone | 50 - 56 | Priceville ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2019/11/priceville.png?fit=32%2C32) | Bulldog Stadium |
2021-10-21 19:00:3510/21/2021 | Lee | 14 - 49 | Russellville ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/russellville.png?fit=32%2C32) | Tigers Stadium |
2021-10-22 19:00:0010/22/2021 | Buckhorn | 20 - 65 | Hartselle ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2019/11/hartselle.png?fit=32%2C32) | J.P. Cain Stadium |
2021-10-22 19:00:0010/22/2021 | Cullman | 7 - 42 | Muscle Shoals ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/muscleshoals.png?fit=32%2C32) | |
2021-10-22 19:00:0010/22/2021 | West Morgan | 20 - 23 | Rogers ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2019/11/rogers.png?fit=32%2C32) | Pirate Field |
2021-10-22 19:00:0010/22/2021 | Albertville | 10 - 62 | James Clemens ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/jamesclemens.png?fit=32%2C32) | |
2021-10-22 19:00:0010/22/2021 | Florence | 62 - 6 | Grissom ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/grissom.png?fit=32%2C32) | Milton Frank Stadium |
2021-10-22 19:00:0310/22/2021 | Whitesburg Christian | 7 - 42 | Ider ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2020/06/ider.gif?fit=32%2C32) | Wayne C. Hardiman Stadium |
2021-10-22 19:00:0410/22/2021 | Columbia | 0 - 47 | Hazel Green ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/hazelgreen.png?fit=32%2C32) | Bob Grimwood Stadium |
2021-10-22 19:00:0710/22/2021 | East Lawrence | 8 - 27 | Colbert Heights ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/colbertheights.png?fit=32%2C32) | Amos Mitchell Stadium |
2021-10-22 19:00:0810/22/2021 | Mae Jemison | 12 - 15 | Ardmore ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2019/11/ardmore.gif?fit=32%2C18) | Ardmore High School |
2021-10-22 19:00:0910/22/2021 | Hubbard | 46 - 0 | Shoals Christian ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/shoalschristian.png?fit=32%2C32) | Flame Field |
2021-10-22 19:00:1810/22/2021 | Sylvania | 35 - 21 | East Limestone ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/eastlimestone.png?fit=32%2C32) | East Limestone Stadium |
2021-10-22 19:00:2110/22/2021 | Hanceville | 14 - 24 | Section ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2020/02/section.jpg?fit=32%2C29) | Section Stadium |
2021-10-22 19:00:2310/22/2021 | Deshler | 28 - 42 | Central-Florence ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/central-florence.png?fit=32%2C32) | Wildcats Stadium |
2021-10-22 19:00:2510/22/2021 | Decatur | 56 - 34 | Athens ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/athens.png?fit=32%2C32) | Golden Eagle Stadium |
2021-10-22 19:00:3610/22/2021 | North Sand Mtn | 29 - 14 | Falkville ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/falkville.png?fit=32%2C32) | Burl Vest Stadium |
2021-10-22 19:00:4310/22/2021 | Tanner | 13 - 14 | Pisgah ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/pisgah.gif?fit=32%2C32) | Sam Kenimer Stadium |
2021-10-22 19:00:5010/22/2021 | Lawrence Co. | 6 - 35 | Brewer ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/brewer.png?fit=32%2C32) | James Tucker Stadium |
2021-10-22 19:00:5610/22/2021 | Decatur Heritage | 53 - 28 | Hackleburg ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/hackleburg.png?fit=32%2C32) | Hackleburg High School |
2021-10-22 19:00:5710/22/2021 | Danville | 28 - 40 | Phil Campbell ![](https://i0.wp.com/mcpreps.site/wp-content/uploads/sites/4/2022/06/philcampbell.png?fit=32%2C32) | Phil Campbell High School |